- AGAINST FRANCE: this kingdom was surrounded by Carlos V's territories. The french king was defeated at the Battle of Pavia in 1525 and Carlos conquered the Duchy of Milan.
- AGAINST THE OTTOMAN EMPIRE: the sultan Suleiman the Magnificient began to expand his empire. in 1529 he attacked Vienna but the city resisted.
- AGAINST THE GERMAN PROTESTANT PRINCES: the emperor fought the protestant princes in the Schmalkaldic War and defeated them in Mülberg.